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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1990 1
1993 2
1994 1
1995 1
1996 1
1997 1
1998 2
1999 3
2001 2
2002 1
2003 3
2004 2
2006 2
2007 4
2008 3
2009 5
2010 3
2011 11
2012 7
2013 5
2014 5
2015 9
2016 11
2017 10
2018 11
2019 9
2020 15
2021 12
2022 14
2023 15
2024 8

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161 results

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Page 1
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A. Anton SE, et al. Cell. 2022 Mar 31;185(7):1130-1142.e11. doi: 10.1016/j.cell.2022.02.011. Epub 2022 Mar 15. Cell. 2022. PMID: 35294858 Free article.
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular functions. Cells express many different GPCRs, but all these GPCRs signal to only a few second messengers such as cAMP. ...The coexistence of many such RAINs allows a single cell to oper …
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular functions. Cells express many different GPCRs, …
RAP2 mediates mechanoresponses of the Hippo pathway.
Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. Meng Z, et al. Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22. Nature. 2018. PMID: 30135582 Free PMC article.
Here we identified the Ras-related GTPase RAP2 as a key intracellular signal transducer that relays ECM rigidity signals to control mechanosensitive cellular activities through YAP and TAZ. ...RAP2, YAP and TAZ have pivotal roles in mechanoregulated transcription, as delet …
Here we identified the Ras-related GTPase RAP2 as a key intracellular signal transducer that relays ECM rigidity signals to control m …
Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial.
Bidard FC, Hardy-Bessard AC, Dalenc F, Bachelot T, Pierga JY, de la Motte Rouge T, Sabatier R, Dubot C, Frenel JS, Ferrero JM, Ladoire S, Levy C, Mouret-Reynier MA, Lortholary A, Grenier J, Chakiba C, Stefani L, Plaza JE, Clatot F, Teixeira L, D'Hondt V, Vegas H, Derbel O, Garnier-Tixidre C, Canon JL, Pistilli B, André F, Arnould L, Pradines A, Bièche I, Callens C, Lemonnier J, Berger F, Delaloge S; PADA-1 investigators. Bidard FC, et al. Lancet Oncol. 2022 Nov;23(11):1367-1377. doi: 10.1016/S1470-2045(22)00555-1. Epub 2022 Sep 29. Lancet Oncol. 2022. PMID: 36183733 Clinical Trial.
Patients with newly present or increased bESR1(mut) in circulating tumour DNA and no synchronous disease progression were randomly assigned (1:1) to continue with the same therapy or to switch to fulvestrant (500 mg intramuscularly on day 1 of each 28-day cycle and on day …
Patients with newly present or increased bESR1(mut) in circulating tumour DNA and no synchronous disease progression were randomly assigned …
Clinical Acquired Resistance to KRAS(G12C) Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation.
Tanaka N, Lin JJ, Li C, Ryan MB, Zhang J, Kiedrowski LA, Michel AG, Syed MU, Fella KA, Sakhi M, Baiev I, Juric D, Gainor JF, Klempner SJ, Lennerz JK, Siravegna G, Bar-Peled L, Hata AN, Heist RS, Corcoran RB. Tanaka N, et al. Cancer Discov. 2021 Aug;11(8):1913-1922. doi: 10.1158/2159-8290.CD-21-0365. Epub 2021 Apr 6. Cancer Discov. 2021. PMID: 33824136 Free PMC article.
To begin to define the mechanistic spectrum of acquired resistance, we describe a patient with KRAS (G12C) NSCLC who developed polyclonal acquired resistance to MRTX849 with the emergence of 10 heterogeneous resistance alterations in serial cell-free DNA spanning four genes (KRAS …
To begin to define the mechanistic spectrum of acquired resistance, we describe a patient with KRAS (G12C) NSCLC who developed polyclonal ac …
The amygdala, a relay station for switching on and off pain.
Rouwette T, Vanelderen P, Roubos EW, Kozicz T, Vissers K. Rouwette T, et al. Eur J Pain. 2012 Jul;16(6):782-92. doi: 10.1002/j.1532-2149.2011.00071.x. Epub 2011 Dec 19. Eur J Pain. 2012. PMID: 22337528 Review.
On the basis of the reviewed literature, we postulate a central mechanism for pain control in which the amygdala plays a critical role by switching on and off chronic pain. In this mechanism, upon pain stimuli, CRFR1 in the amygdala is activated by CRF to induce hyperalges …
On the basis of the reviewed literature, we postulate a central mechanism for pain control in which the amygdala plays a critical role by …
Predicting multiple conformations via sequence clustering and AlphaFold2.
Wayment-Steele HK, Ojoawo A, Otten R, Apitz JM, Pitsawong W, Hömberger M, Ovchinnikov S, Colwell L, Kern D. Wayment-Steele HK, et al. Nature. 2024 Jan;625(7996):832-839. doi: 10.1038/s41586-023-06832-9. Epub 2023 Nov 13. Nature. 2024. PMID: 37956700 Free PMC article.
To test AF-Cluster's sensitivity to point mutations, we designed and experimentally verified a set of three mutations predicted to flip KaiB from Rhodobacter sphaeroides from the ground to the fold-switched state. Finally, screening for alternative states in protein famili …
To test AF-Cluster's sensitivity to point mutations, we designed and experimentally verified a set of three mutations predicted to flip KaiB …
Fluid Ferroelectric Filaments.
Máthé MT, Perera K, Buka Á, Salamon P, Jákli A. Máthé MT, et al. Adv Sci (Weinh). 2024 Mar;11(9):e2305950. doi: 10.1002/advs.202305950. Epub 2023 Dec 21. Adv Sci (Weinh). 2024. PMID: 38126584 Free PMC article.
Ferroelectric nematic fluid threads may have practical applications in nano-fluidic micron-size logic devices, switches, and relays....
Ferroelectric nematic fluid threads may have practical applications in nano-fluidic micron-size logic devices, switches, and relay …
Toward an Integrative Theory of Thalamic Function.
Rikhye RV, Wimmer RD, Halassa MM. Rikhye RV, et al. Annu Rev Neurosci. 2018 Jul 8;41:163-183. doi: 10.1146/annurev-neuro-080317-062144. Epub 2018 Apr 4. Annu Rev Neurosci. 2018. PMID: 29618284 Review.
According to this view, the thalamus is an excitatory feedforward relay to or between cortical regions, and cognitively relevant computations are exclusively cortical. ...Considering their architectural features as well as their ability to initiate, sustain, and switch …
According to this view, the thalamus is an excitatory feedforward relay to or between cortical regions, and cognitively relevant comp …
PI3K signaling through a biochemical systems lens.
Madsen RR, Toker A. Madsen RR, et al. J Biol Chem. 2023 Oct;299(10):105224. doi: 10.1016/j.jbc.2023.105224. Epub 2023 Sep 9. J Biol Chem. 2023. PMID: 37673340 Free PMC article. Review.
Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by the multifaceted nature of the many diseases associated with aberrant PI3K signaling, …
Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that the underlying network does not equate to a si …
Loss of RAP2A Aggravates Cartilage Degradation in TMJOA via YAP Signaling.
Qi H, Zhang Y, Xu L, Zheng X, Li Y, Wei Q, Li Y, Zhao Z, Fang J. Qi H, et al. J Dent Res. 2023 Mar;102(3):302-312. doi: 10.1177/00220345221132213. Epub 2022 Nov 10. J Dent Res. 2023. PMID: 36366779
Ras-related protein Rap-2a (RAP2A) is reportedly a molecular switch that relays extracellular matrix rigidity signals via the Hippo/Yes-associated protein (YAP) pathway. ...RAP2A in chondrocytes regulated the Hippo/YAP pathway directly in response to matrix stiffnes …
Ras-related protein Rap-2a (RAP2A) is reportedly a molecular switch that relays extracellular matrix rigidity signals via the …
161 results